Beilstein J. Org. Chem.2020,16, 2880–2887, doi:10.3762/bjoc.16.237
; polyfluorinatedcarbohydrates; polyfluoroalditol analogues; Introduction
The biological significance of carbohydrates includes, but are not limited to, immune regulation, infection, and cancer metastasis. Research in the field of molecular biology allowed the discovery of glycomimetics to study various
were involved, among other things [5], in binding with UDP-Gal mutase [14], immunoglobulin [15][16], and glycogen phosphorylase [17].
The synthesis of complex polyfluorinatedcarbohydrates is challenging and new synthetic methods must be developed. Pioneering work by many groups brought significant
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Graphical Abstract
Figure 1:
Previously described synthesis of 2,3,4-trifluorinated analogues of galactose 6, glucose 7, mannose ...